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I have smoked this in many different pipes, but I believe this stuff really shines in a meerschaum

Bupropion can slow down how quickly the body metabolizes (gets rid of) certain medications, including some antidepressants (including nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotic medications (including haloperidol, risperidone, and thioridazine) and heart medications known as antiarrhythmics (including amiodarone, propafenone, and flecainide)