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Polyclonal CD4 + Foxp3 + Treg cells induce TGF-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome

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It is worth noting a point of ongoing scholarly discussion around this origin story: BPC-157, as studied, is a fully synthetic sequence, and its status as a naturally occurring fragment of a larger native protein has been questioned in later reviews

On the other hand, much like in the healthy rats (Figure 2A), we demonstrated that immediately after saline or BPC 157 administration, there was consistent normal eye background and normal presentation of the retinal and choroidal blood vessels (IS and IB)