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Inside the ileum cells, B12 binds to another protein, transcobalamin II (TCII), and enters the bloodstream

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Autophagy can be induced by nutrient deprivation, which activates AMPK (a sensor of energy depletion) and inhibits mammalian target of rapamycin (mTOR, an autophagy suppressor), as well as oxidative stress, hypoxia, exercise, drugs (rapamycin, metformin) and hormones (glucagon)