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There may be also issues with instability and degradation (vitamins E and C are quite prone to degradation in solutions) or low interaction of the semi-synthetic derivatives with the delivery systems (such as sodium-dependent vitamin C transporters)

While anorexia is often associated with cancer development, reduced food intake compounded by secondary nutrition derangement is thought to be the core initiator of cancer cachexia

It has been demonstrated that the mechanism of osteosarcoma senescence induction is based on the upregulation of microRNA-200, which subsequently downregulates the ZEB1 and ZEB2 genes [67]