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The immune system infrastructure embedded throughout the gut wall including Peyers patches, mesenteric lymph nodes, and IgA-secreting plasma cells that constitutes approximately 70% of the bodys total immune activity

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Transporter-mediated transportation through BBB The brain-targeted delivery strategy mediated by transporters of the BBB exploits the transport proteins specifically expressed on the BBB (such as the GLUT1 transporter, the L-type amino acid transporter, etc.) to achieve efficient transmembrane drug delivery