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Written by: FormBlends Medical Team | Last reviewed: May 29, 2026 | Sources: PubMed, peer-reviewed pharmacology journals, FDA databases

Metformin has been shown to inhibit autophagy and mitophagy (Van et al., 2023), reducing DOX-induced cardiomyocyte death

Seiwerth, S., et al

3) Metabolic gap acidosis secondary to 5-Oxoproline accumulation 5-Oxoproline is an intermediate metabolite in the gamma-glutamyl cycle shown below in a figure from a nice review in CJASN