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Beyond that narrow application, the cost-benefit calculation shifts rapidly toward harm reduction strategies that don't involve supplementation at all

The protein domains of ATXN3 include an N-terminal Josephin domain with deubiquitylase activity and a C-terminal region bearing 2 or 3 ubiquitin-interacting motifs (UIMs) neighboring the polyQ tract, of still unknown function

When prescribed, peptide therapy is provided under medical supervision with appropriate patient counseling, follow-up, and monitoring based on the individual treatment plan