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At week 4, women in the treatment group displayed improved skin elasticity (+12.7%), reduced wrinkle volume (16.5%), decreased transepidermal water loss (10.8%), increased hydration (+3.5%), and enhanced collagen density compared with baseline values (measured via specialized skin analysis instrumentation)

Furthermore, an increase in IGF-1 levels by around 28% was observed

The 28% collagen increase, 55% wrinkle volume reduction, and 70% elasticity improvement documented in research occurred at the 12-week assessment point

For most users, cyanocobalamin in compounded tirzepatide provides adequate B12 supplementation