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Proteotoxicity: an underappreciated pathology in cardiac disease

doi: 10.3389/fimmu.2022.833355 262 SinhaR.SinhaI.CalcagnottoA.TrushinN.HaleyJ

This conclusion is further supported by modeling of a phosphorylated SF3B1 peptide into previously uninterpreted density in published cryo-EM structures of the activated spliceosome (B act ) 13,16