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Tissue-level pharmacology has been characterised across the major target organs

Lind performed clinical trials comparing citrus juice to dilute sulfuric acid and vinegar and found that only citrus juice caused the sailors to recover, as depicted in the link below

The math works out to between 4 and 25 milligrams of AHK-Cu per milliliter of final product, depending on target concentration

Notably, Ang-2 induced the upregulation of 2 -integrin on monocytes, which interacted with ICAM-1 expressed by endothelial cells and thereby facilitated the migration of monocytes, leading to accumulation of monocyte-derived macrophages in the TME (77)