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The third is the "active clearance" of epithelial cells, which can engulf small molecules of harmful substances through phagocytosis and degrade them through lysosomes

SASP (senescence-associated secretory phenotype) results revealed that FOXO4-DRI downregulates the levels of IL-1 , IL-6 , IL-8 , and TNF- (Figure 4H)

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Peroxisome proliferator-activated receptor coactivator 1 and FoxO3A mediate chondroprotection by AMP-activated protein kinase