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Nevertheless, the results show that the redox environment in the ER is more oxidizing than the cytosol and that GSSG must be generated through an oxidative pathway

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The addition of melatonin, in a micromolar range, prevents LPS-induced iNOS expression in cultured rat endothelial cells and aortic rings 77

Longer circulation times are preferable for brain delivery strategies, with neutral and zwitterionic NPs showing slower clearance from the bloodstream compared with negatively and positively charged NPs, which instead presented shorter half-lives ( Altogether, polymer-based NPs represent a promising and competitive alternative to other conventional carbon-based and bio-based nanostructures eligible for potential clinical applications, such as fullerene, carbon dots (CDs) and nanotubes as well as liposomes (Faiyaz et al., 2021)