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This impairment in mitochondrial function enhances ROS generation and oxidative stress, resulting in damage to neuronal proteins, lipids, and DNA

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The class profile of agents that elevate IGF-1 signaling applies, including the theoretical concern about IGF-1 as a mitogenic and pro-survival signal in malignant cell populations a consideration documented in the FDA-approved labels of recombinant human IGF-1 products (mecasermin), which carry contraindications and warnings related to neoplasia