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RSV may serve as a cardioprotective, antioxidant and anti-inflammatory agent by targeting several major metabolic sensor/effector proteins (e.g., AMPK, SIRT1, and peroxisome proliferator-activated receptor coactivator-1 (PGC-1)) that regulate NF-B in inflamed adipose tissue [221, 222]

Oxidative damage has been linked to high levels of eryptosis through an increase in the intracellular free Ca 2+ concentration, as evidenced by in vitro studies [24, 134, 300, 301] in patients intoxicated with lead [302], and in diabetic patients with chronic renal damage [303]

Other animal wound-model work has been more mixed, including a report of slower reorganization and delayed fibroblast activation

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