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S100A7 lacks the ability of Ca 2+ -binding at the amino acid EF-hand motif, due to the absence of three amino acid residues and non-conserved substitution at position 12 of the EF-hand loop region ( 2+ -binding EF-hand ( Although S100A7 is constitutively expressed at relatively low levels in normal keratinocytes, its expression levels are dramatically increased in psoriatic lesions (81)