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Li D, Gao Q, Xu L, Pang S, Liu Z, Wang C, et al

Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023

Insulin response scales with glucose, limiting hypoglycemia risk relative to non-incretin secretagogues

Moreover, thiols exert antioxidant activity and have in fact been shown to be decreased in the sera of women with fibroids, potentially contributing to the development of these tumors [6]