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The RNA-dependent RNA polymerase (NSP12) and helicase (NSP13) of the replication-transcription complex (RTC) are the most conserved proteins when considering the rate of change at each amino acid site (homologies or nucleic acid diversity) over the course of the SARS-CoV-2 pandemic or conservation in sequence across HCoVs and the coronavirus family [62]

Its function has been shown to be agonistic with endothelial nitric oxide synthase (eNOS) (Li J

[DOI] [PubMed] [Google Scholar] 41.Kwekkeboom DJ, Teunissen JJ, Bakker WH, et al

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