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This pulsatile release proves critical because many of growth hormones beneficial effects require rhythmic patterns of exposure

Tesamorelin is an FDA-approved synthetic growth hormonereleasing hormone analogue that stimulates IGF-1 production to reduce visceral abdominal fat in HIV-associated lipodystrophy, though its use outside this population remains unproven

where X= various amino acids] of Angiotensin IV analogs, bind directly to Hepatocyte Growth Factor (HGF) and inhibit HGF's ability to form functional dimers

77 This complex picture has been nicely reviewed by Connell and Venkataraman 78 and is summarized in Figure 5