At the same time, desmosterol, the immediate precursor of cholesterol in the Bloch biosynthetic pathway, together with oxysterols, binds to and activates LXRs, leading to up-regulation of genes involved in cholesterol efflux, such as ATP-binding cassette sub-family A member 1 (ABCA1), ATP-binding cassette sub-family G member 1 (ABCG1), ATP-binding cassette sub-family G member 5 (ABCG5) and ATP-binding cassette sub-family G member 8 (ABCG8), and others such as myosin regulatory light chain interacting protein (MYLIP)
An alternative conservative start uses 1mg for the first four weeks before moving to 2mg
Liver enlargement in rodents attributable to nongenotoxic microsomal enzyme induction that is greater than 140% has been reported to lead to liver tumor development in male C57BL/10J mice (Greaves 1996)
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