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Fibronectin-binding protein A (FnbA), which is a key surface-attached proteins and ECM-binding protein homologue (Ebh), a giant cell wall-related protein associated with virulence, are both key surface proteins, and therefore we examined the transcription level of these genes during the initial period of biofilm formation (2 h) in response to nicotine treatment

This would seem to suggest that "frequent" would be more often than in 1 in 100 patients and "rare" less than 1 in 1,000 patients

Availability How likely a person is to be addicted to any substance is partly determined by its availability

One independent review concluded vaping was about 95% less harmful than smoking