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Because pyridostigmine is a highly ionized quaternary ammonium compound, under normal conditions it does not readily cross the blood-brain barrier (BBB) (Dunn et al, 1997

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According to the requestor (the manufacturer of the EKOS TM device), USAT of peripheral vascular structures with the administration of thrombolytic(s) for the treatment of DVT performed using the EKOS TM device utilizes more resources in comparison to other procedures that are currently assigned to MS-DRGs 252, 253, and 254 and is not clinically coherent with the other procedures assigned to those MS-DRGs