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Think of the IRR as a "Master Switch" for healing that exists on the surface of cells, particularly immune cells and nerve cells

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Eur J Cardiothorac Surg 57(2):331-337, 2020

This post-translational modification promotes the formation of an R-loop structure between chromatin-associated circRNA SCN8A and the non-host SLC7A11 promoter, thereby regulating the transcriptional activity of SLC7A11 [143]