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After the FDA tried to force Puff Bar off the market, the company relaunched and said it was now using laboratory-made nicotine, which didnt fall under FDAs original oversight of tobacco-derived nicotine

References (1) What Is the Tobacco and Vapes Act 2026

We developed a search string to search for studies reporting any association between binary smoking status (that is, current, former and ever smokers) and the five CVD outcomes from 1 January 1970 to 31 May 2022, and included only studies reporting age-specific risk (RR, odds ratio (OR), hazard ratio (HR)) of smoking status

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