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Using the crude abstinence rate of about 8% in the placebo group and the meta-analytical risk ratio of 2.57 from this review of cessing smoking after taking bupropion, the calculated required minimum sample size for a trial of 5% statistically significance and 80% power is 136 (calculation according to Statcalc in EpiInfo version 3.5.1 for Windows (Centers for Disease Control and Prevention, Atlanta, see www.cdc.gov/epiinfo/epiinfo.htm))

Journal of the American College of Nutrition

According to the new analysis, the outbreak's characteristics align much more closely with smallpox than chickenpox

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