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Jiao Cheng (73) found that melatonin could suppress OS-induced HIF-1/ROS/VEGF signaling and inhibit the proliferation of endothelial cellsindicating that the activation of HIF-1 is an important angiogenic process

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The brain relies on rapid ATP turnover, especially during complex cognitive tasks or high neural activity, with creatine facilitating ATP regeneration through the creatine phosphate system [16]

In another study, employing the MPP + PD animal model, the supernatant from human umbilical cord (hUC) MSCs infected by an adenovirus carrying the HGF gene promotes a better regeneration of damaged PD dopaminergic neurons as compared to hUC-MSCs alone