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Molecular modeling suggests that trigonelline has a high affinity for the A(142) peptide, similar to cotinine, a proposed drug candidate for neurodegenerative diseases, based on docking and in vivo studies [63]

However, it is more than a behavioral-only diagnosis

doi:10.1152/japplphysiol.00068.2012 Berk M, Copolov DL, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Bush AI (2008) N -acetyl cysteine for depressive symptoms in bipolar disordera double-blind randomized placebo-controlled trial