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Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)

51 Whilst mean baseline levels for FSH and LH in study participants were within normal range, median levels were borderline high, suggesting that a considerable number of participants may have had elevated levels of LH and/or FSH

Use extra virgin olive oil to make homemade salad dressings, add some to sauces, or use it as a flavor-boosting ingredient for stir-fries or marinades

This allows for a dose-dependent relationship to be established, as well as allowing the authors to gauge what dosages will affect micro vs macro level measurements