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Current evidence suggests GHK-Cu may provide moderate adjunctive benefits in pigmentation disorder management when combined with established treatments including hydroquinone, kojic acid, or laser therapies, rather than serving as a primary depigmenting agent

However, there are still challenges that need to be addressed, such as the optimization of properties, reliable characterization methods, safety evaluation, nanoparticles that might lead to unintended consequences like nano-pollution and cytotoxicity and regulatory aspects related to nanomedicines targeting skin cancer [176, 179]

Strong antioxidant Free radicals damage the skin cells that cause various skin issues like dark spots, fine lines, and wrinkles

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