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However, the extent of treatment is unknown because there are insufficient data on whether smokers received only brief interventions or participated in behavioral counselling 40

One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30

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