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This is why bioavailabilitythe degree and rate at which a substance is absorbed into a living systemis the most important factor to consider

Established CSF markers of neurodegeneration, including neurofilament light chain (NfL), t-tau, and AD-related amyloid/tau signaturesparticularly reduced A42 and composite ratios such as p-tau/A42 or A42/40have been associated with shunt outcome, but with limited and inconsistent predictive accuracy 3438