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Rudin CM, Liu SV, Soo RA, Lu S, Hong MH, Lee JS, et al

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The integration of LSTM and CNN enables the model to leverage both temporal and spatial features, allowing it to more effectively address the inherent complexity and variability of skin lesion images

However, the recovery of these regenerative capabilities (by increased expression of NAMPT for example) change the physiology of the cells towards stem-like cells, gaining some cancer properties, such as unlimited proliferative capacity, altered metabolism, DNA-repair, methylation alterations, with phenotype similar to CSCs, which deregulation by any other mutation initiate the tumor