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Well-structured treatments lasting 6-12 months with appropriate concentrations typically maintain noticeable improvements over pre-treatment baseline including reduced fine lines (though not eliminated as during peak treatment), improved skin texture and firmness (though less dramatic than treatment peak), better overall skin quality and appearance (though aging continues at normal rates), and resolved specific issues like scarring or hyperpigmentation (which typically remain improved permanently if successfully treated)

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These processes result in the detachment of, among others, the ZO protein from the TJ complex and impair integrity of the TJ [16, 18, 66,67,68,69]

Generally, BP consists of carbohydrates (4085%), proteins (1430%), lipids (110%), vitamins, minerals, carotenoids, phenolics, and other trace elements (Table 1)