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MeitzlerJLAntonySWuYJuhaszALiuHJiangGet al

4 Potential mechanisms of RAS blockers-induced antidepressant/anxiolytic effects 4.1 RAS-related gene and development of depression The main RAS-related gene polymorphisms are found in the angiotensinogen gene, ACE, and the angiotensin 1 receptor gene, which have alleles associated with high levels of Ang II, high ACE activity, and elevated Ang II response, respectively