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Trypanosomes exhibit several features of eukaryotic cell apoptosis, including loss of mitochondrial membrane potential, cytochrome c release, cell shrinkage, and DNA fragmentation, although the exact mechanisms involved in PCD of trypanosomatids and its biological relevance is still under debate (De Souza et al., 2019)

Importantly, the oral co-administration of NAC successfully reversed all these changes, restoring GSH, reducing oxidative markers, and normalizing neurotransmitter levels

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Rescue potential of P-PantSAc in HoPan treated mice In order to test the rescue potential of P-PantSAc in vivo in an established mammalian setting, we used HoPan-treated mice as previously described 34