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In addition, avoiding direct comparison between the harms of traditional cigarettes and ENDS is recommended due to existing uncertainties, in particular those related to the high prevalence of dual or multiple product use, the variability of types/generations of ENDS and in their levels of nicotine content, and to a lack of rigourous and standardised comparative studies

Frontier analysis indicates that several countries remain at the forefront of disease burden (Supplementary file Figure S6)

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