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In preclinical tests, the most commonly noted side effect was mild local irritation at the injection site

GSH depletion modestly increased the weight of BAT, but the weights of liver and other metabolic organs, such as eWAT, iWAT, and muscle, were unchanged (Supplemental Figure 5, BF)

MEK blockade converts AML differentiating response to retinoic acid (RA) into extensive apoptosis: Involvement of Bcl-2 modulation and ROS accumulation