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The real differentiator may be the metabolic preservation effects seen with CagriSema in preclinical models, but human data confirming this advantage is still limited

Disruption of circadian rhythms disturbs the balance between pro- and anti-inflammatory cytokines, partly through altered immune cell trafficking and dysregulated clock proteins such as REV-ERB/NR1D1 (93).Innate immune cells such as macrophages and NK cells contain functional circadian clocks, with the CLOCK:BMAL1 heterodimer regulating phagocytosis, cytokine production (e.g., IL-1, TNF-), and antimicrobial activity (94)