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[30] the inhibitory effect of selenium on the growth of microorganisms could be based on nonspecific incorporation of seleno-amino acids (SeMet, SeCys) instead of methionine and cysteine in proteins

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There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs

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