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in Cell Metabolism , increased NAD availability stimulates PGC-1 through SIRT1 activation, leading to enhanced mitochondrial function and improved metabolic flexibility (Cant et al., Cell Metabolism )

Neither did selenium status decrease in lipedema with increasing BMI in contrast to lymphedema

n the production and degradation of reactive oxygen species is lost

Hypoxia-inducible factors (HIFs) orchestrate adaptive transcriptional programs that enhance glycolysis, angiogenesis, acidosis, and survival signaling, while metabolic rewiring toward aerobic glycolysis, glutaminolysis, and lipid metabolism supports rapid proliferation and therapeutic resistance