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The amount of panduratin A elimination via the urine was negligible, at approximately 110% of the administered dose, and excretion through the feces was dominant, at approximately 2260% of the administered dose

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In the pathology of RA, IL-6 can stimulate pannus formation through increased vascular endothelial growth factor expression and increase bone resorption as a result of osteoclastogenesis, as well as oxidative stress in leukocytes