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The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

299 , 300 , 301 , 302 , 303 (See Detection, Screening, and Diagnosis in the Workforce section for a discussion of barriers to timely and accurate diagnosis from the perspective of primary care physicians.) Because dementia is often underdiagnosed and if it is diagnosed by a clinician, some people appear to be unaware of their diagnosis a large portion of Americans with dementia may not know they have it