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In a renal proximal tubule-specific Tsc1 gene-knockout mouse model, downregulated AMPK phosphorylation was observed in the enlarged kidneys, which also exhibited aberrant proliferation of proximal tubule cells, renal interstitial inflammation, and fibrosis

In oral squamous cell carcinoma, erianin exerts anticancer effects through a dual mechanism: Erianin blocks the cell cycle in the G2/M phase, activates the apoptosis program and regulates autophagy (34) and induces autophagy-dependent apoptosis by inhibiting the palmitoyl-protein thioesterase 1/mTOR signaling pathway (35) and regulating the MAPK pathway (36)

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