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demonstrated that the flavoring agent cinnamaldehyde markedly suppressed ciliary beat frequency and diminished phagocytic activity of immune cells, thereby directly compromising respiratory innate defense mechanisms (60)

The reported population-level trends in smoking, the countrys longest-running epidemic, might be a result of distinct, time-varying factors like age (association between age and smoking status), and/or period (differences in smoking prevalence due to changing sociocultural environments that shape smoking practices collectively among all individuals), and/or cohort (shifts in smoking status among groups of individuals that belong to different generations) 1,5,6

Together, these results suggest that MI-181 warrants further evaluation within the context of developing therapeutics for smoke-related airway diseases that are characterized by defective motile cilia