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Based on the Bagged CART integrated algorithm and metabolomics features, diabetic retinopathy subtypes (NDR/NPDR/PDR) can be effectively classified with an accuracy of 72% and a sensitivity of 91.9%, proving that artificial intelligence models can assist in the early detection and accurate classification of diabetic complications (134)

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As mentioned in the section above, IDH1 catalyzes typically the conversion of isocitrate to -KG, but the mutant isoform converts -KG into D-2HG instead, which has been shown to inhibit cellular differentiation through epigenetic alterations [19]