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Chronic use leads to compensatory upregulation of NMDA and downregulation of GABA, causing CNS hyperexcitability on withdrawal the basis of alcohol withdrawal seizures and delirium tremens (F10.231, F10.232)

After being noticed looking particularly frail in the summer of 2008, Newman shut down rumours concerning his health, saying that he was only being treated for athlete's foot and hair loss. However, by September of the same year news of Newmans death was made public