doi: 10.1073/pnas.2101718118 43 CircuM
The PNPLA3 I148M polymorphism is more frequently present in the Hispanic population, less in those of European descent, and lowest in African-American populations (Romeo et al., 2008)
The counteracting cellular antioxidant systems include both enzymatic, such as catalase, superoxide dismutase (SOD), glutathione peroxidase, and nonenzymatic, such as glutathione (GSH), vitamin C, vitamin E, members (Haida and Hakiman 2019)
Therefore, considering that there is a lot of evidence about the role of senescence on insulin resistance and inflammation as the main problems in obesity and related disorders and even resistance to weight loss, it seems that reduce or prevent senescence can be used as a therapeutic solution in the treatment of obesity and its complications