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Herein, we provide evidence that hepatic GSSG accumulation, which was observed in a high-fat diet (HFD)-fed model of NAFLD, rendered hepatocytes susceptible to TNF-induced cell death

In a study evaluating the neuroprotective potential of cynomenine as well as its effect on oxidative stress and inflammation in a rat model of temporal lobe epilepsy induced by intrahippocampal kainate, it was reported that GSH production decreased, ROS and MDA levels increased and Nuclear Factor kappa B (NFB) and Tumour necrosis factor-alpha (TNF-) levels increased [87]

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