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doi: 10.1016/j.freeradbiomed.2014.05.008

Mannila A, Rautio J, Lehtonen M, Jrvinen T, Savolainen J

One famous sufferer was Queen's pianist and lead singer Freddie Mercury

[70] reported that high uric acid can downregulate the Nrf2/SLC7A11/GPX4 pathway to induce ferroptosis in macrophages, which is involved in the formation of atherosclerotic plaques