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The ideal frequency of injections for you will depend on your specific health goals, nutritional needs, and response to treatment

Certain health conditions or medications may interact with B12 shots

On-Label vs Off-Label and Compounded Products Vitamin B12 injections are an established medical treatment for confirmed B12 deficiency and related conditions (for example, pernicious anemia and certain malabsorption states), as summarized by the NIH Office of Dietary Supplements in its Vitamin B12 fact sheet for health professionals