The direct influence of the E4 allele on FA-related bioenergetics (i.e., the transport and use of metabolites, in this case FAs, for energy) within the cerebrovasculature requires further attention, specifically in E4 carriers because of their increased cerebrovascular vulnerability observed with age which could impair nutrient transport to the brain and affect proper neuronal and glial functioning (Ojo et al., 2021)
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RStudio and R-3.2.2 ( was used for all statistical analysis, and significance was accepted at p 2 points or 1 SD in VABS-II composite scores were used to discriminate responders. Out of the 19 who completed the behavioral assessments in the CRWP group, 12 were identified as responders vs
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